Nature Communications (Sep 2017)
Tumor-associated B-cells induce tumor heterogeneity and therapy resistance
- Rajasekharan Somasundaram,
- Gao Zhang,
- Mizuho Fukunaga-Kalabis,
- Michela Perego,
- Clemens Krepler,
- Xiaowei Xu,
- Christine Wagner,
- Denitsa Hristova,
- Jie Zhang,
- Tian Tian,
- Zhi Wei,
- Qin Liu,
- Kanika Garg,
- Johannes Griss,
- Rufus Hards,
- Margarita Maurer,
- Christine Hafner,
- Marius Mayerhöfer,
- Georgios Karanikas,
- Ahmad Jalili,
- Verena Bauer-Pohl,
- Felix Weihsengruber,
- Klemens Rappersberger,
- Josef Koller,
- Roland Lang,
- Courtney Hudgens,
- Guo Chen,
- Michael Tetzlaff,
- Lawrence Wu,
- Dennie Tompers Frederick,
- Richard A. Scolyer,
- Georgina V. Long,
- Manashree Damle,
- Courtney Ellingsworth,
- Leon Grinman,
- Harry Choi,
- Brian J. Gavin,
- Margaret Dunagin,
- Arjun Raj,
- Nathalie Scholler,
- Laura Gross,
- Marilda Beqiri,
- Keiryn Bennett,
- Ian Watson,
- Helmut Schaider,
- Michael A. Davies,
- Jennifer Wargo,
- Brian J. Czerniecki,
- Lynn Schuchter,
- Dorothee Herlyn,
- Keith Flaherty,
- Meenhard Herlyn,
- Stephan N. Wagner
Affiliations
- Rajasekharan Somasundaram
- The Wistar Institute
- Gao Zhang
- The Wistar Institute
- Mizuho Fukunaga-Kalabis
- The Wistar Institute
- Michela Perego
- The Wistar Institute
- Clemens Krepler
- The Wistar Institute
- Xiaowei Xu
- Department of Pathology and Medicine, Perelman School of Medicine, University of Pennsylvania
- Christine Wagner
- Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, Medical University of Vienna
- Denitsa Hristova
- The Wistar Institute
- Jie Zhang
- New Jersey Institute of Technology
- Tian Tian
- New Jersey Institute of Technology
- Zhi Wei
- New Jersey Institute of Technology
- Qin Liu
- The Wistar Institute
- Kanika Garg
- Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, Medical University of Vienna
- Johannes Griss
- Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, Medical University of Vienna
- Rufus Hards
- The Wistar Institute
- Margarita Maurer
- Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, Medical University of Vienna
- Christine Hafner
- Department of Dermatology and Venereology, Karl Landsteiner University of Health Sciences
- Marius Mayerhöfer
- Department of Radiology, Division of Nuclear Medicine, Medical University of Vienna
- Georgios Karanikas
- Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna
- Ahmad Jalili
- Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, Medical University of Vienna
- Verena Bauer-Pohl
- Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, Medical University of Vienna
- Felix Weihsengruber
- Department of Dermatology and Venereology, The Rudolfstiftung Hospital, Teaching Hospital of the Medical University Vienna
- Klemens Rappersberger
- Department of Dermatology and Venereology, The Rudolfstiftung Hospital, Teaching Hospital of the Medical University Vienna
- Josef Koller
- Department of Dermatology, Paracelsus Medical University Salzburg
- Roland Lang
- Department of Dermatology, Paracelsus Medical University Salzburg
- Courtney Hudgens
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Guo Chen
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Michael Tetzlaff
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Lawrence Wu
- The Wistar Institute
- Dennie Tompers Frederick
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Richard A. Scolyer
- Melanoma Institute of Australia, and The University of Sydney
- Georgina V. Long
- Melanoma Institute of Australia, and The University of Sydney
- Manashree Damle
- The Wistar Institute
- Courtney Ellingsworth
- The Wistar Institute
- Leon Grinman
- The Wistar Institute
- Harry Choi
- The Wistar Institute
- Brian J. Gavin
- The Wistar Institute
- Margaret Dunagin
- Department of Bioengineering, University of Pennsylvania
- Arjun Raj
- Department of Bioengineering, University of Pennsylvania
- Nathalie Scholler
- Abramson Cancer Center, Hospital of University of Pennsylvania
- Laura Gross
- The Wistar Institute
- Marilda Beqiri
- The Wistar Institute
- Keiryn Bennett
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Ian Watson
- Department of Biochemistry, McGill University
- Helmut Schaider
- Dermatology Research Center, University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute
- Michael A. Davies
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Jennifer Wargo
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer, Center
- Brian J. Czerniecki
- Abramson Cancer Center, Hospital of University of Pennsylvania
- Lynn Schuchter
- Abramson Cancer Center, Hospital of University of Pennsylvania
- Dorothee Herlyn
- The Wistar Institute
- Keith Flaherty
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Meenhard Herlyn
- The Wistar Institute
- Stephan N. Wagner
- Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, Medical University of Vienna
- DOI
- https://doi.org/10.1038/s41467-017-00452-4
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Resistance to BRAFV600E inhibitors often occurs in melanoma patients. Here, the authors describe a potential mechanism of acquired drug resistance mediated by tumor-associated B cells-derived IGF-1.
