Journal of Electrical Bioimpedance (Aug 2019)

Segmental intracellular, interstitial, and intravascular volume changes during simulated hemorrhage and resuscitation: A case study

  • Montgomery Leslie D.,
  • Montgomery Richard W.,
  • Gerth Wayne A.,
  • Bodo Michael,
  • Stewart Julian M.,
  • Loughry Marty

DOI
https://doi.org/10.2478/joeb-2019-0006
Journal volume & issue
Vol. 10, no. 1
pp. 40 – 46

Abstract

Read online

This paper describes a new combined impedance plethysmographic (IPG) and electrical bioimpedance spectroscopic (BIS) instrument and software that will allow noninvasive real-time measurement of segmental blood flow, intracellular, interstitial, and intravascular volume changes during various fluid management procedures. The impedance device can be operated either as a fixed frequency IPG for the quantification of segmental blood flow and hemodynamics or as a multi-frequency BIS for the recording of intracellular and extracellular resistances at 40 discrete input frequencies. The extracellular volume is then deconvoluted to obtain its intravascular and interstitial component volumes as functions of elapsed time. The purpose of this paper is to describe this instrumentation and to demonstrate the information that can be obtained by using it to monitor segmental compartment volume responses of a pig model during simulated hemorrhage and resuscitation. Such information may prove valuable in the diagnosis and management of rapid changes in the body fluid balance and various clinical treatments.

Keywords