Effect of pranoprofen pretreatment on pupil diameter in diabetic patients during femtosecond-assisted cataract surgery

Abstract

Objective To investigate the effect of preoperative application of nonsteroidal anti-inflammatory drugs (NSAIDs) on pupil diameter (PD) in diabetic patients during femtosecond laser-assisted cataract surgery (FLACS). Methods A total of 80 patients (40 diabetic patients and 40 patients with normal blood glucose) who underwent FLACS in our hospital from January 2018 to February 2019 were prospectively recruited in this study. The 40 eyes of the diabetic patients and 40 eyes from the non-diabetic patients were randomly divided into 2 groups (20 eyes in each group). Those receiving 0.1% pranoprofen (4 times per day, in 1 d before surgery) served as the trial group, and those without such pretreatment as the control group. The PD at each time point within 30 min after FLACS was observed. Results Within 30 min after FLACS, PD was increased firstly and then decreased in all the patients, with in a small range when compared to the pre-operative value. At the observed time points within 30 min, there was no obvious difference in PD between the patients receiving pranoprofen pretreatment but with diabetes and not, and between those without pranoprofen pretreatment but with diabetes and not (P>0.05). Conclusion Pranoprofen pretreatment shows no effect on PD in diabetic patients undergoing FLACS

Keywords

• femtosecond-assisted cataract surgery
• pupil diameter
• diabetes mellitus
• nonsteroidal anti-inflammatory drugs