Anti-Hyperlipidemic Effect of <i>Ruta chalepensis</i> Ethanolic Extract in Triton WR-1339-Induced Hyperlipidemia in Rats

Abstract

High levels of fats like triglycerides and cholesterol in the blood can cause cardiovascular diseases, prompting the search for safer, natural treatments. This study investigates the efficacy of Ruta chalepensis ethanol extract in lowering cholesterol levels using a rat model of hyperlipidemia induced by Triton WR-1339. Leaves and flowers of R. chalepensis were extracted with ethanol, and LC-MS analysis revealed high levels of quercetin (9.5%), 2,2-Dimethyl-3-methylidenebicyclo [2.2.1] heptane (8.1%), and other compounds, with monoterpenes being the most common class. Male Wistar rats received doses of the extract at 20 and 40 mg/kg, while fenofibrate (100 mg/kg) was the positive control. After 20 h, plasma lipid levels were significantly affected, showing a 72.1% reduction in total cholesterol for the 40 mg/kg group (p p p p p p p p R. chalepensis extract is a promising natural alternative for managing hyperlipidemia.

Keywords

• <i>Ruta chalepensis</i>
• anti-hyperlipidemic activity
• hyperlipidemia
• Triton WR-1339
• lipid profiles
• LC-MS