Altered Connectivity of the Frontoparietal Network During Attention Processing in Prolactinomas

Chenglong Cao; Chenglong Cao; Yu Wang; Jia Liu; Aobo Chen; Jinjiang Lu; Guozheng Xu; Guozheng Xu; Jian Song; Jian Song

doi:10.3389/fneur.2021.638851

Frontiers in Neurology (Aug 2021)

Altered Connectivity of the Frontoparietal Network During Attention Processing in Prolactinomas

Chenglong Cao,
Chenglong Cao,
Yu Wang,
Jia Liu,
Aobo Chen,
Jinjiang Lu,
Guozheng Xu,
Guozheng Xu,
Jian Song,
Jian Song

Affiliations

Chenglong Cao: Department of Neurosurgery, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China
Chenglong Cao: Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands
Yu Wang: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China
Jia Liu: Foreign Linguistics and Applied Linguistics, Research Institute of Foreign Languages, Beijing Foreign Studies University, Beijing, China
Aobo Chen: Department of Neurosurgery, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China
Jinjiang Lu: Department of Neurosurgery, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China
Guozheng Xu: Department of Neurosurgery, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China
Guozheng Xu: Department of Neurosurgery, The General Hospital of Chinese PLA Central Theater Command, Wuhan, China
Jian Song: Department of Neurosurgery, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China
Jian Song: Department of Neurosurgery, The General Hospital of Chinese PLA Central Theater Command, Wuhan, China

DOI: https://doi.org/10.3389/fneur.2021.638851
Journal volume & issue: Vol. 12

Abstract

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Prolactinomas have been reported for the failure of cognitive functions. However, the electrophysiological mechanisms of attention processing in prolactinomas remain unclear. In a visual mission, we monitored the scalp electroencephalography (EEG) of the participants. Compared with the healthy controls (HCs), larger frontoparietal theta and alpha coherence were found in the patients, especially in the right-lateralized hemisphere, which indicated a deficit in attention processing. Moreover, the frontoparietal coherence was positively correlated with altered prolactin (PRL) levels, implying the significance of PRL for adaptive brain compensation in prolactinomas. Taken together, this research showed the variations in attention processing between the HCs and prolactinomas. The coherence between frontal and parietal regions may be one of the possible electrophysiological biomarkers for detecting deficient attention processing in prolactinomas.

Published in Frontiers in Neurology

ISSN: 1664-2295 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.frontiersin.org/journals/neurology/

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