Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5

Abstract

Amino acid levels are known to regulate anabolic and catabolic pathways. Here, the authors report that amino acids also affect membrane trafficking by stimulating endosome-to-Golgi retrograde trafficking and regulating cell surface localization of certain Golgi proteins through Ragulator and Arl5.