New Pyrimidinone Bearing Aminomethylenes and Schiff Bases as Potent Antioxidant, Antibacterial, SARS-CoV-2, and COVID-19 Main Protease MPro Inhibitors: Design, Synthesis, Bioactivities, and Computational Studies

• Muhammad Sarfraz,
• Muhammad Ayyaz,
• Abdul Rauf,
• Asma Yaqoob,
• Tooba,
• Muhammad Arif Ali,
• Sabir Ali Siddique,
• Ashfaq Mahmood Qureshi,
• Muhammad Hassan Sarfraz,
• Reem M. Aljowaie,
• Saeedah Musaed Almutairi,
• Muhammad Arshad

Affiliations

Muhammad Sarfraz

Institute of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Muhammad Ayyaz

Institute of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Abdul Rauf

Institute of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Asma Yaqoob

Institute of Biochemistry, Biotechnology, and Bioinformatics. Department of Biochemistry and Molecular Biology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Tooba

Institute of Biochemistry, Biotechnology, and Bioinformatics. Department of Biochemistry and Molecular Biology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Muhammad Arif Ali

Institute of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Sabir Ali Siddique

Institute of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Ashfaq Mahmood Qureshi

Department of Chemistry, Government Sadiq College Women University, Bahawalpur, Pakistan

Muhammad Hassan Sarfraz

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Institute of Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom

Reem M. Aljowaie

Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia

Saeedah Musaed Almutairi

Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia

Muhammad Arshad

Institute of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan