Antidiabetic, tyrosinase inhibitory, and free radical scavenging activities of the purified extracts from Morinda citrifolia unripe fruits

Abstract

The crude extracts from medicinal plants are increasingly important for bioactive activities. Several parts of Morinda citrifolia have been utilized in traditional medicine, such as diabetes, anticancer, and hypertension. Therefore, the purpose of this research was to investigate the biological activities, e.g., antioxidant, antidiabetic, and tyrosinase inhibitory activity of the crude extracts of Morinda citrifolia unripe fruits. The highest percent extraction was found in methanol. The purified methanoic fraction displayed the highest total phenolic content and was a potent tyrosinase inhibitor. The fraction of ethyl acetate exhibited the highest flavonoid content and DPPH free radical scavenging capacity. Furthermore, the ethyl acetate and methanol fractions were investigated as potent -glucosidase and -amylase inhibitors. Additionally, the cytotoxicity test of the bioactive fractions was explored in human keratinocyte cell lines.

Keywords

• morinda citrifolia unripe fruit extract
• tyrosinase inhibition
• glucosidase inhibition
• amylase inhibition
• free radical scavenging