Establishment of external prescription database for facial pigmentation skin disease and mining of medication pattern

Abstract

Objective To explore the regularity of external-use Chinese medicine agents for curing freckle and chloasma.Methods To screening the external prescriptions for freckles and chloasma recorded in ancient books. The Excel data recording system was used to build an external prescription database of Chinese medicines for facial pigmentation skin disease. The frequency analysis and correlation analysis of 115 external prescriptions were carried out to summarize the common herbs, external application method, matrix, common Chinese medicine pairs and drug groups in the treatment of freckle and chloasma. Results Although with different causes of disease and different western medicine methods for freckles and chloasma, the external prescriptions of Chinese medicine were similar in ancient literature, Mainly including Baizhi, Baifuzi, Baiji, Bailian and Fuling, etc. Common drug pairs and drug groups included Baidingxiang, Baizhi, Baiji, Baifuzi, Bailian and Gansong, etc. The most commonly external-used method was rubbing and cleansing,with chicken egg white and honey as most popular drug matrix.Conclusion Common drugs, matrix drugs, drug pairs and external application methods for freckles and chloasma found by data mining analysis can provide ideas and references for clinical treatment and developing beauty products.

Keywords

• facial pigmentation skin disease
• freckle
• chloasma
• external use
• medication pattern
• data mining