Secohellebrigeninamide

Abstract

The title compound, C26H37NO5, was the reaction product of hellebrigenin with N,N-dimethylformamide. It consists of three cyclohexane rings (A, B and C), one five-membered ring (D) and one dihydropyran ring (E). The stereochemistry of the ring junctions is is A/B cis, B/C trans, C/D cis and C/E trans. The cyclohexane rings A, B and C have chair conformations. Both the five-membered ring D and the dihydropyran ring adopt an envelope conformation. Two orientations are found for the aldehyde group with occupancies of 0.608 (10) and 0.392 (10). In the crystal, short O—H...O hydrogen bonds and short C—H...O contacts involving the hydroxy group, terminal methyl group and carbonyl group link the molecules into a three-dimensional network.