T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling

Abstract

The strength and duration of interleukin-2 (IL-2) signals is known to regulate T cell memory. Here the authors show that T cell receptor signalling strength controls the requirement for IL-2 signals to form CD8+ T cell memory with high functional activity and a wide range of genes with open chromatin regions.