The causal effect of oxidative stress on the risk of glaucoma

Ronghua Shi; Yaxuan Wu; He Chen; Zicheng Zhang; Siqi Bao; Jia Qu; Meng Zhou

Heliyon (Feb 2024)

The causal effect of oxidative stress on the risk of glaucoma

Ronghua Shi,
Yaxuan Wu,
He Chen,
Zicheng Zhang,
Siqi Bao,
Jia Qu,
Meng Zhou

Affiliations

Ronghua Shi: School of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou 570228, China; Hainan Institute of Real World Data, Qionghai, 571437, China
Yaxuan Wu: School of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou 570228, China; Hainan Institute of Real World Data, Qionghai, 571437, China
He Chen: School of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou 570228, China; Hainan Institute of Real World Data, Qionghai, 571437, China
Zicheng Zhang: School of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou 570228, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China; Hainan Institute of Real World Data, Qionghai, 571437, China
Siqi Bao: School of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou 570228, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China; Hainan Institute of Real World Data, Qionghai, 571437, China
Jia Qu: School of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou 570228, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China; Hainan Institute of Real World Data, Qionghai, 571437, China; Corresponding author. School of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou 570228, China.
Meng Zhou: National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China; Corresponding author.

Journal volume & issue: Vol. 10, no. 3
p. e24852

Abstract

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Glaucoma is a complex multifactorial disease. Oxidative stress has been implicated in its pathogenesis. However, establishing a causal relationship between oxidative stress and glaucoma is challenging due to confounding and reverse causality. In this study, we performed bidirectional two-sample Mendelian randomization (MR) analyses based on genetic instrumental variables as proxies for 11 biomarkers of oxidative stress injury to investigate the causal relationship between oxidative stress and glaucoma. Eight significant associations were identified. Increased circulating levels of catalase (OR = 0.915, 95 % CI: 0.848–0.987, P = 0.022), retinol (OR = 0.481, 95 % CI: 0.248–0.932, P = 0.044) and superoxide dismutase (OR = 0.779, 95 % CI: 0. 616-0.986, P = 0.038) are associated with a decreased risk of glaucoma, whereas an increased myeloperoxidase level (OR = 2.145, 95 % CI: 1.119–4.111, P = 0.029) is associated with an increased risk of glaucoma. Glaucoma was causally associated with lower levels of total bilirubin (OR = 0.961, 95 % CI: 0.927–0.997, P = 0.039), glutathione peroxidase (OR = 0. 934, 95 % CI: 0.890–0.981, P = 0.006), paraoxonase (OR = 0.883, 95 % CI: 0.810–0.963, P = 0.005) and albumin (OR = 0.988, 95 % CI: 0.978–0.998, P = 0.014). The bidirectional MR analysis revealed a causal relationship between oxidative stress and glaucoma. These findings provide a greater understanding of the underlying mechanisms of glaucomatous neurodegeneration and imply a potential therapeutic approach for glaucoma through targeting oxidative stress pathways.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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