Frontiers in Neurology (Apr 2023)

Should we treat pediatric radiologically isolated syndrome? An 18-year follow-up case report

  • Elena Barbuti,
  • Riccardo Nistri,
  • Riccardo Nistri,
  • Antonio Ianniello,
  • Antonio Ianniello,
  • Carlo Pozzilli,
  • Carlo Pozzilli,
  • Serena Ruggieri,
  • Serena Ruggieri

DOI
https://doi.org/10.3389/fneur.2023.1145260
Journal volume & issue
Vol. 14

Abstract

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BackgroundRadiologically isolated syndrome (RIS) describes asymptomatic individuals with incidental radiologic abnormalities suggestive of multiple sclerosis (MS). Much of RIS literature is about adult-onset cases. Treatment of RIS is controversial, especially in pediatric age, but early treatment in selected patients might improve long-term outcomes.Case presentationWe report a single RIS patient who followed up for 18 years in our MS center. At first, she was only monitored with follow-up MRIs. Then, as the lesion load increased, she was treated with a first-line disease-modifying treatment (DMT) reaching MRI stability.ConclusionThis report highlights how treatment can be an appropriate choice in pediatric forms of RIS.

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