Communications Biology (Mar 2021)

Structure of the p53/RNA polymerase II assembly

  • Shu-Hao Liou,
  • Sameer K. Singh,
  • Robert H. Singer,
  • Robert A. Coleman,
  • Wei-Li Liu

DOI
https://doi.org/10.1038/s42003-021-01934-4
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 12

Abstract

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Liou et al. report a 4.6 Å resolution structure of the human p53/ RNA polymerase II assembly, using single particle cryoelectron microscopy. This study suggests that p53’s functional domains regulate the DNA binding activity of RNA polymerase II, providing insights into p53-regulated gene expression.