Nature Communications (Apr 2016)
Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression
- Matthias Eden,
- Benjamin Meder,
- Mirko Völkers,
- Montatip Poomvanicha,
- Katrin Domes,
- M. Branchereau,
- P. Marck,
- Rainer Will,
- Alexander Bernt,
- Ashraf Rangrez,
- Matthias Busch,
- German Mouse Clinic Consortium,
- Martin Hrabě de Angelis,
- Christophe Heymes,
- Wolfgang Rottbauer,
- Patrick Most,
- Franz Hofmann,
- Norbert Frey
Affiliations
- Matthias Eden
- Department of Internal Medicine III (Cardiology and Angiology), University Hospital Schleswig-Holstein, Campus Kiel
- Benjamin Meder
- Department of Internal Medicine III, University of Heidelberg
- Mirko Völkers
- Department of Internal Medicine III, University of Heidelberg
- Montatip Poomvanicha
- Department of Pharmacology, University of Technology Munich
- Katrin Domes
- Department of Pharmacology, University of Technology Munich
- M. Branchereau
- Inserm U1048 - Institut des Maladies Métaboliques et Cardiovasculaires (I2MC)/Equipe 13
- P. Marck
- Inserm U1048 - Institut des Maladies Métaboliques et Cardiovasculaires (I2MC)/Equipe 13
- Rainer Will
- Department of Internal Medicine III, University of Heidelberg
- Alexander Bernt
- German Centre for Cardiovascular Research
- Ashraf Rangrez
- German Centre for Cardiovascular Research
- Matthias Busch
- Department of Internal Medicine III, University of Heidelberg
- German Mouse Clinic Consortium
- Martin Hrabě de Angelis
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Christophe Heymes
- Inserm U1048 - Institut des Maladies Métaboliques et Cardiovasculaires (I2MC)/Equipe 13
- Wolfgang Rottbauer
- Department of Internal Medicine III, Cardiology and Angiology, University Hospital of Ulm
- Patrick Most
- Department of Internal Medicine III, University of Heidelberg
- Franz Hofmann
- Department of Pharmacology, University of Technology Munich
- Norbert Frey
- Department of Internal Medicine III (Cardiology and Angiology), University Hospital Schleswig-Holstein, Campus Kiel
- DOI
- https://doi.org/10.1038/ncomms11317
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
Heart failure is a major public health issue but due to our poor disease understanding the current therapies are symptomatic. Here the authors identify Myoscape as a novel cardiac protein regulating membrane localization of the L-type calcium channel and heart's contractile force, thus promising new therapeutic avenues for heart failure.
