Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles

Jingchao Li; Yu Luo; Ziling Zeng; Dong Cui; Jiaguo Huang; Chenjie Xu; Liping Li; Kanyi Pu; Ruiping Zhang

doi:10.1038/s41467-022-31551-6

Nature Communications (Jul 2022)

Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles

Jingchao Li,
Yu Luo,
Ziling Zeng,
Dong Cui,
Jiaguo Huang,
Chenjie Xu,
Liping Li,
Kanyi Pu,
Ruiping Zhang

Affiliations

Jingchao Li: School of Chemical and Biomedical Engineering, Nanyang Technological University
Yu Luo: School of Chemical Science and Engineering, Tongji University
Ziling Zeng: School of Chemical and Biomedical Engineering, Nanyang Technological University
Dong Cui: School of Chemical and Biomedical Engineering, Nanyang Technological University
Jiaguo Huang: School of Chemical and Biomedical Engineering, Nanyang Technological University
Chenjie Xu: School of Chemical and Biomedical Engineering, Nanyang Technological University
Liping Li: The Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences
Kanyi Pu: School of Chemical and Biomedical Engineering, Nanyang Technological University
Ruiping Zhang: The Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences

DOI: https://doi.org/10.1038/s41467-022-31551-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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To improve the specificity of immunotherapy, here the authors report the design of a semiconducting polymer immunomodulatory nanoparticle with sonodynamic process to remotely release immune-modulators for deep-tissue precision cancer sono-immunotherapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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