Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter

Alexandros A. Pittis; Valerie Goh; Alberto Cebrian-Serrano; Jennifer Wettmarshausen; Fabiana Perocchi; Toni Gabaldón

doi:10.1038/s41467-020-17705-4

Nature Communications (Aug 2020)

Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter

Alexandros A. Pittis,
Valerie Goh,
Alberto Cebrian-Serrano,
Jennifer Wettmarshausen,
Fabiana Perocchi,
Toni Gabaldón

Affiliations

Alexandros A. Pittis: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Valerie Goh: Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München
Alberto Cebrian-Serrano: Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München
Jennifer Wettmarshausen: Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München
Fabiana Perocchi: Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München
Toni Gabaldón: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology

DOI: https://doi.org/10.1038/s41467-020-17705-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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The mitochondrial calcium uptake system, crucial for cellular processes, evolved in ancient eukaryotes. Here, authors perform a phylogenomic analysis across 1,156 eukaryotes, and show that previously identified animal and fungal genes in this system originated from an ancestral duplication.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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