The Effectiveness of Endurance Training and Nano Curcumin Consumption on Short-Term Memory in Mice with Glioblastoma Multiforme Brain Tumor

Abstract

Background & Purpose: Brain tumors are one of the deadliest malignancies that can directly affect the brain, and are often accompanied by executive function and memory disorders. The aim of this research was to investigate the effectiveness of endurance exercise and nano curcumin consumption on short-term memory of rats with glioblastoma multiforme brain tumor. Materials & Methods: In this experimental study, 35 healthy male Wistar rats were randomly divided into seven groups of five including: the basic healthy control group, 4-week healthy control, basic cancer control, 4-week cancer control, cancer + nano curcumin group, cancer + exercise, and cancer + practice + nano curcumin. One week after the injection of cancer cells into the frontal cortex, the animals entered the main exercise program on the treadmill (4 weeks, 18 m/min, and 3 days a week). In the end, the rats were sacrificed, the data were collected, and the results were analyzed using one-way analysis of variance and Tukey's post hoc statistical tests. Results: The results showed that endurance exercise and nano curcumin consumption significantly reduced the tumor volume in the cancer + exercise + nano curcumin group (P= 0.001), and also caused a significant increase in short-term memory in the studied groups compared to the 4-week cancer group (P= 0.001). Conclusion: Probably, performing endurance exercises along with the use of nano curcumin can improve short-term memory in rats with brain tumors, in addition to reducing tumor volume.

Keywords

• brain tumor
• endurance training
• nano curcumin supplement
• short-term memory
• glioblastoma multiforme