Frontiers in Immunology (Dec 2022)

Case report: Durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma

  • Chien-Hsiang Kao,
  • Chien-Ting Liu,
  • Hao Lin,
  • Yung-Cheng Huang,
  • Jui Lan,
  • Yu-Che Ou,
  • Yu-Che Ou,
  • Hung-Chun Fu,
  • Chen-Hsuan Wu,
  • Chen-Hsuan Wu

DOI
https://doi.org/10.3389/fimmu.2022.1079253
Journal volume & issue
Vol. 13

Abstract

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Advanced endometrial clear cell carcinoma (CCC) tends to have poor prognosis owing to aggressive clinical behavior and poor response to conventional chemotherapy. Herein, we report a case of platinum-refractory recurrent ECCC successfully treated with the combination of pembrolizumab, localized radiotherapy and a few cycles of chemotherapy with an extremely durable response even after cessation of immunotherapy for 3 years at the time of publication.

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