Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel

Seu-Na Lee; Hwa-Jin Cho; Hyeongseop Jeong; Bumhan Ryu; Hyuk-Joon Lee; Minsoo Kim; Jejoong Yoo; Jae-Sung Woo; Hyung Ho Lee

doi:10.1038/s41467-023-37040-8

Nature Communications (Mar 2023)

Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel

Seu-Na Lee,
Hwa-Jin Cho,
Hyeongseop Jeong,
Bumhan Ryu,
Hyuk-Joon Lee,
Minsoo Kim,
Jejoong Yoo,
Jae-Sung Woo,
Hyung Ho Lee

Affiliations

Seu-Na Lee: Department of Life Sciences, Korea University
Hwa-Jin Cho: Department of Chemistry, College of Natural Sciences, Seoul National University
Hyeongseop Jeong: Center for Research Equipment, Korea Basic Science Institute
Bumhan Ryu: Research Solution Center, Institute for Basic Science
Hyuk-Joon Lee: Department of Life Sciences, Korea University
Minsoo Kim: Department of Physics, Sungkyunkwan University
Jejoong Yoo: Department of Physics, Sungkyunkwan University
Jae-Sung Woo: Department of Life Sciences, Korea University
Hyung Ho Lee: Department of Chemistry, College of Natural Sciences, Seoul National University

DOI: https://doi.org/10.1038/s41467-023-37040-8
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 15

Abstract

Read online

Connexin 36 (Cx36) gap junction channel is responsible for signal transmission in electrical synapses. Here, the authors determine cryo-EM structures of Cx36, providing insights into a potential role of lipids in the channel gating.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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