A novel role for TTK in homologous recombination: implications for breast cancer radiosensitivity

Abstract

Basal-like breast cancers have the highest rates of locoregional recurrence after radiation. By correlating gene expression with early locoregional recurrence, we nominate TTK protein kinase as a mediator of radioresistance. TTK inhibition radiosensitizes in vitro and in vivo through a novel mechanism of impaired homologous recombination and represents a promising translational strategy.

Keywords

• breast cancer
• ttk
• radiation sensitivity
• homologous recombination