Nature Communications (Aug 2022)

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

  • Qingbo S. Wang,
  • Ryuya Edahiro,
  • Ho Namkoong,
  • Takanori Hasegawa,
  • Yuya Shirai,
  • Kyuto Sonehara,
  • Hiromu Tanaka,
  • Ho Lee,
  • Ryunosuke Saiki,
  • Takayoshi Hyugaji,
  • Eigo Shimizu,
  • Kotoe Katayama,
  • Masahiro Kanai,
  • Tatsuhiko Naito,
  • Noah Sasa,
  • Kenichi Yamamoto,
  • Yasuhiro Kato,
  • Takayoshi Morita,
  • Kazuhisa Takahashi,
  • Norihiro Harada,
  • Toshio Naito,
  • Makoto Hiki,
  • Yasushi Matsushita,
  • Haruhi Takagi,
  • Masako Ichikawa,
  • Ai Nakamura,
  • Sonoko Harada,
  • Yuuki Sandhu,
  • Hiroki Kabata,
  • Katsunori Masaki,
  • Hirofumi Kamata,
  • Shinnosuke Ikemura,
  • Shotaro Chubachi,
  • Satoshi Okamori,
  • Hideki Terai,
  • Atsuho Morita,
  • Takanori Asakura,
  • Junichi Sasaki,
  • Hiroshi Morisaki,
  • Yoshifumi Uwamino,
  • Kosaku Nanki,
  • Sho Uchida,
  • Shunsuke Uno,
  • Tomoyasu Nishimura,
  • Takashri Ishiguro,
  • Taisuke Isono,
  • Shun Shibata,
  • Yuma Matsui,
  • Chiaki Hosoda,
  • Kenji Takano,
  • Takashi Nishida,
  • Yoichi Kobayashi,
  • Yotaro Takaku,
  • Noboru Takayanagi,
  • Soichiro Ueda,
  • Ai Tada,
  • Masayoshi Miyawaki,
  • Masaomi Yamamoto,
  • Eriko Yoshida,
  • Reina Hayashi,
  • Tomoki Nagasaka,
  • Sawako Arai,
  • Yutaro Kaneko,
  • Kana Sasaki,
  • Etsuko Tagaya,
  • Masatoshi Kawana,
  • Ken Arimura,
  • Kunihiko Takahashi,
  • Tatsuhiko Anzai,
  • Satoshi Ito,
  • Akifumi Endo,
  • Yuji Uchimura,
  • Yasunari Miyazaki,
  • Takayuki Honda,
  • Tomoya Tateishi,
  • Shuji Tohda,
  • Naoya Ichimura,
  • Kazunari Sonobe,
  • Chihiro Tani Sassa,
  • Jun Nakajima,
  • Yasushi Nakano,
  • Yukiko Nakajima,
  • Ryusuke Anan,
  • Ryosuke Arai,
  • Yuko Kurihara,
  • Yuko Harada,
  • Kazumi Nishio,
  • Tetsuya Ueda,
  • Masanori Azuma,
  • Ryuichi Saito,
  • Toshikatsu Sado,
  • Yoshimune Miyazaki,
  • Ryuichi Sato,
  • Yuki Haruta,
  • Tadao Nagasaki,
  • Yoshinori Yasui,
  • Yoshinori Hasegawa,
  • Yoshikazu Mutoh,
  • Tomoki Kimura,
  • Tomonori Sato,
  • Reoto Takei,
  • Satoshi Hagimoto,
  • Yoichiro Noguchi,
  • Yasuhiko Yamano,
  • Hajime Sasano,
  • Sho Ota,
  • Yasushi Nakamori,
  • Kazuhisa Yoshiya,
  • Fukuki Saito,
  • Tomoyuki Yoshihara,
  • Daiki Wada,
  • Hiromu Iwamura,
  • Syuji Kanayama,
  • Shuhei Maruyama,
  • Takashi Yoshiyama,
  • Ken Ohta,
  • Hiroyuki Kokuto,
  • Hideo Ogata,
  • Yoshiaki Tanaka,
  • Kenichi Arakawa,
  • Masafumi Shimoda,
  • Takeshi Osawa,
  • Hiroki Tateno,
  • Isano Hase,
  • Shuichi Yoshida,
  • Shoji Suzuki,
  • Miki Kawada,
  • Hirohisa Horinouchi,
  • Fumitake Saito,
  • Keiko Mitamura,
  • Masao Hagihara,
  • Junichi Ochi,
  • Tomoyuki Uchida,
  • Rie Baba,
  • Daisuke Arai,
  • Takayuki Ogura,
  • Hidenori Takahashi,
  • Shigehiro Hagiwara,
  • Genta Nagao,
  • Shunichiro Konishi,
  • Ichiro Nakachi,
  • Koji Murakami,
  • Mitsuhiro Yamada,
  • Hisatoshi Sugiura,
  • Hirohito Sano,
  • Shuichiro Matsumoto,
  • Nozomu Kimura,
  • Yoshinao Ono,
  • Hiroaki Baba,
  • Yusuke Suzuki,
  • Sohei Nakayama,
  • Keita Masuzawa,
  • Shinichi Namba,
  • Takayuki Shiroyama,
  • Yoshimi Noda,
  • Takayuki Niitsu,
  • Yuichi Adachi,
  • Takatoshi Enomoto,
  • Saori Amiya,
  • Reina Hara,
  • Yuta Yamaguchi,
  • Teruaki Murakami,
  • Tomoki Kuge,
  • Kinnosuke Matsumoto,
  • Yuji Yamamoto,
  • Makoto Yamamoto,
  • Midori Yoneda,
  • Kazunori Tomono,
  • Kazuto Kato,
  • Haruhiko Hirata,
  • Yoshito Takeda,
  • Hidefumi Koh,
  • Tadashi Manabe,
  • Yohei Funatsu,
  • Fumimaro Ito,
  • Takahiro Fukui,
  • Keisuke Shinozuka,
  • Sumiko Kohashi,
  • Masatoshi Miyazaki,
  • Tomohisa Shoko,
  • Mitsuaki Kojima,
  • Tomohiro Adachi,
  • Motonao Ishikawa,
  • Kenichiro Takahashi,
  • Takashi Inoue,
  • Toshiyuki Hirano,
  • Keigo Kobayashi,
  • Hatsuyo Takaoka,
  • Kazuyoshi Watanabe,
  • Naoki Miyazawa,
  • Yasuhiro Kimura,
  • Reiko Sado,
  • Hideyasu Sugimoto,
  • Akane Kamiya,
  • Naota Kuwahara,
  • Akiko Fujiwara,
  • Tomohiro Matsunaga,
  • Yoko Sato,
  • Takenori Okada,
  • Yoshihiro Hirai,
  • Hidetoshi Kawashima,
  • Atsuya Narita,
  • Kazuki Niwa,
  • Yoshiyuki Sekikawa,
  • Koichi Nishi,
  • Masaru Nishitsuji,
  • Mayuko Tani,
  • Junya Suzuki,
  • Hiroki Nakatsumi,
  • Takashi Ogura,
  • Hideya Kitamura,
  • Eri Hagiwara,
  • Kota Murohashi,
  • Hiroko Okabayashi,
  • Takao Mochimaru,
  • Shigenari Nukaga,
  • Ryosuke Satomi,
  • Yoshitaka Oyamada,
  • Nobuaki Mori,
  • Tomoya Baba,
  • Yasutaka Fukui,
  • Mitsuru Odate,
  • Shuko Mashimo,
  • Yasushi Makino,
  • Kazuma Yagi,
  • Mizuha Hashiguchi,
  • Junko Kagyo,
  • Tetsuya Shiomi,
  • Satoshi Fuke,
  • Hiroshi Saito,
  • Tomoya Tsuchida,
  • Shigeki Fujitani,
  • Mumon Takita,
  • Daiki Morikawa,
  • Toru Yoshida,
  • Takehiro Izumo,
  • Minoru Inomata,
  • Naoyuki Kuse,
  • Nobuyasu Awano,
  • Mari Tone,
  • Akihiro Ito,
  • Yoshihiko Nakamura,
  • Kota Hoshino,
  • Junichi Maruyama,
  • Hiroyasu Ishikura,
  • Tohru Takata,
  • Toshio Odani,
  • Masaru Amishima,
  • Takeshi Hattori,
  • Yasuo Shichinohe,
  • Takashi Kagaya,
  • Toshiyuki Kita,
  • Kazuhide Ohta,
  • Satoru Sakagami,
  • Kiyoshi Koshida,
  • Kentaro Hayashi,
  • Tetsuo Shimizu,
  • Yutaka Kozu,
  • Hisato Hiranuma,
  • Yasuhiro Gon,
  • Namiki Izumi,
  • Kaoru Nagata,
  • Ken Ueda,
  • Reiko Taki,
  • Satoko Hanada,
  • Kodai Kawamura,
  • Kazuya Ichikado,
  • Kenta Nishiyama,
  • Hiroyuki Muranaka,
  • Kazunori Nakamura,
  • Naozumi Hashimoto,
  • Keiko Wakahara,
  • Sakamoto Koji,
  • Norihito Omote,
  • Akira Ando,
  • Nobuhiro Kodama,
  • Yasunari Kaneyama,
  • Shunsuke Maeda,
  • Takashige Kuraki,
  • Takemasa Matsumoto,
  • Koutaro Yokote,
  • Taka-Aki Nakada,
  • Ryuzo Abe,
  • Taku Oshima,
  • Tadanaga Shimada,
  • Masahiro Harada,
  • Takeshi Takahashi,
  • Hiroshi Ono,
  • Toshihiro Sakurai,
  • Takayuki Shibusawa,
  • Yoshifumi Kimizuka,
  • Akihiko Kawana,
  • Tomoya Sano,
  • Chie Watanabe,
  • Ryohei Suematsu,
  • Hisako Sageshima,
  • Ayumi Yoshifuji,
  • Kazuto Ito,
  • Saeko Takahashi,
  • Kota Ishioka,
  • Morio Nakamura,
  • Makoto Masuda,
  • Aya Wakabayashi,
  • Hiroki Watanabe,
  • Suguru Ueda,
  • Masanori Nishikawa,
  • Yusuke Chihara,
  • Mayumi Takeuchi,
  • Keisuke Onoi,
  • Jun Shinozuka,
  • Atsushi Sueyoshi,
  • Yoji Nagasaki,
  • Masaki Okamoto,
  • Sayoko Ishihara,
  • Masatoshi Shimo,
  • Yoshihisa Tokunaga,
  • Yu Kusaka,
  • Takehiko Ohba,
  • Susumu Isogai,
  • Aki Ogawa,
  • Takuya Inoue,
  • Satoru Fukuyama,
  • Yoshihiro Eriguchi,
  • Akiko Yonekawa,
  • Keiko Kan-o,
  • Koichiro Matsumoto,
  • Kensuke Kanaoka,
  • Shoichi Ihara,
  • Kiyoshi Komuta,
  • Yoshiaki Inoue,
  • Shigeru Chiba,
  • Kunihiro Yamagata,
  • Yuji Hiramatsu,
  • Hirayasu Kai,
  • Koichiro Asano,
  • Tsuyoshi Oguma,
  • Yoko Ito,
  • Satoru Hashimoto,
  • Masaki Yamasaki,
  • Yu Kasamatsu,
  • Yuko Komase,
  • Naoya Hida,
  • Takahiro Tsuburai,
  • Baku Oyama,
  • Minoru Takada,
  • Hidenori Kanda,
  • Yuichiro Kitagawa,
  • Tetsuya Fukuta,
  • Takahito Miyake,
  • Shozo Yoshida,
  • Shinji Ogura,
  • Shinji Abe,
  • Yuta Kono,
  • Yuki Togashi,
  • Hiroyuki Takoi,
  • Ryota Kikuchi,
  • Shinichi Ogawa,
  • Tomouki Ogata,
  • Shoichiro Ishihara,
  • Arihiko Kanehiro,
  • Shinji Ozaki,
  • Yasuko Fuchimoto,
  • Sae Wada,
  • Nobukazu Fujimoto,
  • Kei Nishiyama,
  • Mariko Terashima,
  • Satoru Beppu,
  • Kosuke Yoshida,
  • Osamu Narumoto,
  • Hideaki Nagai,
  • Nobuharu Ooshima,
  • Mitsuru Motegi,
  • Akira Umeda,
  • Kazuya Miyagawa,
  • Hisato Shimada,
  • Mayu Endo,
  • Yoshiyuki Ohira,
  • Masafumi Watanabe,
  • Sumito Inoue,
  • Akira Igarashi,
  • Masamichi Sato,
  • Hironori Sagara,
  • Akihiko Tanaka,
  • Shin Ohta,
  • Tomoyuki Kimura,
  • Yoko Shibata,
  • Yoshinori Tanino,
  • Takefumi Nikaido,
  • Hiroyuki Minemura,
  • Yuki Sato,
  • Yuichiro Yamada,
  • Takuya Hashino,
  • Masato Shinoki,
  • Hajime Iwagoe,
  • Hiroshi Takahashi,
  • Kazuhiko Fujii,
  • Hiroto Kishi,
  • Masayuki Kanai,
  • Tomonori Imamura,
  • Tatsuya Yamashita,
  • Masakiyo Yatomi,
  • Toshitaka Maeno,
  • Shinichi Hayashi,
  • Mai Takahashi,
  • Mizuki Kuramochi,
  • Isamu Kamimaki,
  • Yoshiteru Tominaga,
  • Tomoo Ishii,
  • Mitsuyoshi Utsugi,
  • Akihiro Ono,
  • Toru Tanaka,
  • Takeru Kashiwada,
  • Kazue Fujita,
  • Yoshinobu Saito,
  • Masahiro Seike,
  • Hiroko Watanabe,
  • Hiroto Matsuse,
  • Norio Kodaka,
  • Chihiro Nakano,
  • Takeshi Oshio,
  • Takatomo Hirouchi,
  • Shohei Makino,
  • Moritoki Egi,
  • Yosuke Omae,
  • Yasuhito Nannya,
  • Takafumi Ueno,
  • Tomomi Takano,
  • Kazuhiko Katayama,
  • Masumi Ai,
  • Atsushi Kumanogoh,
  • Toshiro Sato,
  • Naoki Hasegawa,
  • Katsushi Tokunaga,
  • Makoto Ishii,
  • Ryuji Koike,
  • Yuko Kitagawa,
  • Akinori Kimura,
  • Seiya Imoto,
  • Satoru Miyano,
  • Seishi Ogawa,
  • Takanori Kanai,
  • Koichi Fukunaga,
  • Yukinori Okada

DOI
https://doi.org/10.1038/s41467-022-32276-2
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

Read online

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.