TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis

Daniel Sidler; Ping Wu; Rana Herro; Meike Claus; Dennis Wolf; Yuko Kawakami; Toshiaki Kawakami; Linda Burkly; Michael Croft

doi:10.1038/ncomms15395

Nature Communications (May 2017)

TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis

Daniel Sidler,
Ping Wu,
Rana Herro,
Meike Claus,
Dennis Wolf,
Yuko Kawakami,
Toshiaki Kawakami,
Linda Burkly,
Michael Croft

Affiliations

Daniel Sidler: Division of Immune Regulation, La Jolla Institute for Allergy and Immunology
Ping Wu: Department of Immunology
Rana Herro: Division of Immune Regulation, La Jolla Institute for Allergy and Immunology
Meike Claus: Division of Immune Regulation, La Jolla Institute for Allergy and Immunology
Dennis Wolf: Inflammation Biology, La Jolla Institute for Allergy and Immunology
Yuko Kawakami: Cell Biology, La Jolla Institute for Allergy and Immunology
Toshiaki Kawakami: Cell Biology, La Jolla Institute for Allergy and Immunology
Linda Burkly: Department of Immunology
Michael Croft: Division of Immune Regulation, La Jolla Institute for Allergy and Immunology

DOI: https://doi.org/10.1038/ncomms15395
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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TWEAK is a TNF family member that binds the NFκB signalling receptor Fn14. Here the authors show that TWEAK is central to skin inflammation in mouse models of atopic dermatitis and psoriasis and causes similar pathology when injected subcutaneously into mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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