Nature Communications (Jan 2020)

Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10

  • Yuguang Zhao,
  • Daming Zhou,
  • Tao Ni,
  • Dimple Karia,
  • Abhay Kotecha,
  • Xiangxi Wang,
  • Zihe Rao,
  • E. Yvonne Jones,
  • Elizabeth E. Fry,
  • Jingshan Ren,
  • David I. Stuart

DOI
https://doi.org/10.1038/s41467-019-13936-2
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 8

Abstract

Read online

Here, the authors provide the structure of mature Coxsackie Virus A10 alone and in complex with its receptor KREMEN1, and of A-particles. This shows how the receptor spans the viral canyon and suggests that receptor binding triggers pocket factor release and conformational changes resulting in expanded particles.