Drug release from a two-layer stent coating considering the viscoelastic property of the arterial wall: A mathematical and numerical study

Abstract

Atherosclerosis is one of the most common diseases in the world. Med-ication with metal stents plays an important role in treating this disease. There are many models for delivering drugs from stents to the arterial wall. This paper presents a model that describes drug delivery from the stent coating layers to the arterial wall tissue. This model complements the previous models by considering the mec hanical properties of the arte-rial wall tissue, which changes due to atherosclerosis and improves results for designing stents. The stability behavior of the model is analyzed, and a number of numerical results are provided with explanations. A compar-ison between numerical and experimental results, which examine a more accurate match between the in vivo and in vitro, is shown.

Keywords

• stent coating
• viscoelastic
• mathematical model
• numerical simulation