Asymmetric construction of allylicstereogenic carbon center featuring atrifluoromethyl group via enantioselective reductive fluoroalkylation

Ruo-Xing Jin; Bing-Bing Wu; Kang-Jie Bian; Jian-Liang Yu; Jing-Cheng Dai; Ya-Wen Zuo; Yi-Fan Zhang; Xi-Sheng Wang

doi:10.1038/s41467-022-34841-1

Nature Communications (Nov 2022)

Asymmetric construction of allylicstereogenic carbon center featuring atrifluoromethyl group via enantioselective reductive fluoroalkylation

Ruo-Xing Jin,
Bing-Bing Wu,
Kang-Jie Bian,
Jian-Liang Yu,
Jing-Cheng Dai,
Ya-Wen Zuo,
Yi-Fan Zhang,
Xi-Sheng Wang

Affiliations

Ruo-Xing Jin: Department of Chemistry, University of Science and Technology of China
Bing-Bing Wu: Department of Chemistry, University of Science and Technology of China
Kang-Jie Bian: Department of Chemistry, University of Science and Technology of China
Jian-Liang Yu: Department of Chemistry, University of Science and Technology of China
Jing-Cheng Dai: Department of Chemistry, University of Science and Technology of China
Ya-Wen Zuo: Department of Chemistry, University of Science and Technology of China
Yi-Fan Zhang: Department of Chemistry, University of Science and Technology of China
Xi-Sheng Wang: Department of Chemistry, University of Science and Technology of China

DOI: https://doi.org/10.1038/s41467-022-34841-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 8

Abstract

Read online

The efficient construction of trifluoromethylated alkanes bearing a CF3 chiral center is of great importance in organic synthesis. Here, the authors disclose the enantioselective syntheses of α-trifluoromethylated allylic alkanes via reductive trifluoroalkylation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal