S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo

Fernando Real; Aiwei Zhu; Boxin Huang; Ania Belmellat; Alexis Sennepin; Thomas Vogl; Céline Ransy; Marc Revol; Riccardo Arrigucci; Anne Lombès; Johannes Roth; Maria Laura Gennaro; Frédéric Bouillaud; Sarra Cristofari; Morgane Bomsel

doi:10.1038/s41467-022-33401-x

Nature Communications (Oct 2022)

S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo

Fernando Real,
Aiwei Zhu,
Boxin Huang,
Ania Belmellat,
Alexis Sennepin,
Thomas Vogl,
Céline Ransy,
Marc Revol,
Riccardo Arrigucci,
Anne Lombès,
Johannes Roth,
Maria Laura Gennaro,
Frédéric Bouillaud,
Sarra Cristofari,
Morgane Bomsel

Affiliations

Fernando Real: Laboratory of Mucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Université Paris Cité
Aiwei Zhu: Laboratory of Mucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Université Paris Cité
Boxin Huang: Laboratory of Mucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Université Paris Cité
Ania Belmellat: Laboratory of Mucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Université Paris Cité
Alexis Sennepin: Laboratory of Mucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Université Paris Cité
Thomas Vogl: Institute of Immunology and Interdisciplinary Center for Clinical Research, University of Münster
Céline Ransy: CNRS, UMR8104
Marc Revol: Plastic, Reconstructive and Aesthetic Surgery Department, Saint Louis Hospital
Riccardo Arrigucci: Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey
Anne Lombès: CNRS, UMR8104
Johannes Roth: Institute of Immunology and Interdisciplinary Center for Clinical Research, University of Münster
Maria Laura Gennaro: Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey
Frédéric Bouillaud: CNRS, UMR8104
Sarra Cristofari: Plastic, Reconstructive and Aesthetic Surgery Department, Saint Louis Hospital
Morgane Bomsel: Laboratory of Mucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Université Paris Cité

DOI: https://doi.org/10.1038/s41467-022-33401-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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HIV-1 eradication is hindered by viral persistence in different cell reservoirs, including circulatory CD4+ T-cells and tissue-resident macrophages. Here, by analyzing male genital mucosa from cART-suppressed HIV1-infected individuals, Real et al. show that M4 macrophages represent the major macrophage HIV-1 reservoir in this tissue. These macrophages have an inflammatory IL1R+S100A8+MMP7+M4-phenotype, and contain transcriptionally active HIV-1, which reactivate infectious virus production from viral latency in response to autocrine/paracrine S100A8-mediated glycolysis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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