PAN-CANCER INTEGRATIVE HISTOLOGY-GENOMIC ANALYSIS VIA INTERPRETABLE MULTIMODAL DEEP LEARNING

• Richard J. Chen,
• Ming Y. Lu,
• Drew F.K. Williamson,
• Tiffany Y. Chen,
• Jana Lipkova,
• Muhammad Shaban,
• Maha Shady,
• Mane Williams,
• Bumjin Joo,
• Zahra Noor,
• Faisal Mahmood

Affiliations

Richard J. Chen

Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Cancer Data Science Program, Dana-Farber Cancer Institute, Boston, MA, USA

Ming Y. Lu

Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Cancer Data Science Program, Dana-Farber Cancer Institute, Boston, MA, USA

Drew F.K. Williamson

Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA

Tiffany Y. Chen

Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA

Jana Lipkova

Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Cancer Data Science Program, Dana-Farber Cancer Institute, Boston, MA, USA

Muhammad Shaban

Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Cancer Data Science Program, Dana-Farber Cancer Institute, Boston, MA, USA

Maha Shady

Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA

Mane Williams

Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA

Bumjin Joo

Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Zahra Noor

Department of Computer Science, Harvard University, Cambridge, MA, USA

Faisal Mahmood

Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Cancer Data Science Program, Dana-Farber Cancer Institute, Boston, MA, USA; Corresponding author.