Nature Communications (Aug 2021)

Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus

  • Gu-Lung Lin,
  • Simon B. Drysdale,
  • Matthew D. Snape,
  • Daniel O’Connor,
  • Anthony Brown,
  • George MacIntyre-Cockett,
  • Esther Mellado-Gomez,
  • Mariateresa de Cesare,
  • David Bonsall,
  • M. Azim Ansari,
  • Deniz Öner,
  • Jeroen Aerssens,
  • Christopher Butler,
  • Louis Bont,
  • Peter Openshaw,
  • Federico Martinón-Torres,
  • Harish Nair,
  • Rory Bowden,
  • RESCEU Investigators,
  • Tanya Golubchik,
  • Andrew J. Pollard

DOI
https://doi.org/10.1038/s41467-021-25265-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Respiratory syncytial virus (RSV) is a common infection in children and older adults but little is known about within-host viral population diversity. Here, the authors perform deep sequencing and find that RSV subgroup B exhibited more diversity than subgroup A, with implications for development of therapeutics and vaccines.