Nature Communications (Aug 2021)
Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice
- Eunee Lee,
- Seungjoon Lee,
- Jae Jin Shin,
- Woochul Choi,
- Changuk Chung,
- Suho Lee,
- Jihye Kim,
- Seungmin Ha,
- Ryunhee Kim,
- Taesun Yoo,
- Ye-Eun Yoo,
- Jisoo Kim,
- Young Woo Noh,
- Issac Rhim,
- Soo Yeon Lee,
- Woohyun Kim,
- Taekyung Lee,
- Hyogeun Shin,
- Il-Joo Cho,
- Karl Deisseroth,
- Sang Jeong Kim,
- Joo Min Park,
- Min Whan Jung,
- Se-Bum Paik,
- Eunjoon Kim
Affiliations
- Eunee Lee
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- Seungjoon Lee
- Department of Biological Sciences, KAIST
- Jae Jin Shin
- Department of Brain and Cognitive Science, College of Natural Science, Seoul National University
- Woochul Choi
- Program of Brain and Cognitive Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute for Science and Technology (KAIST)
- Changuk Chung
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- Suho Lee
- Department of Biological Sciences, KAIST
- Jihye Kim
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- Seungmin Ha
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- Ryunhee Kim
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- Taesun Yoo
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- Ye-Eun Yoo
- Department of Biological Sciences, KAIST
- Jisoo Kim
- Department of Biological Sciences, KAIST
- Young Woo Noh
- Department of Biological Sciences, KAIST
- Issac Rhim
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- Soo Yeon Lee
- Department of Biological Sciences, KAIST
- Woohyun Kim
- Department of Biological Sciences, KAIST
- Taekyung Lee
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- Hyogeun Shin
- Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST)
- Il-Joo Cho
- Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST)
- Karl Deisseroth
- Department of Bioengineering, Department of Psychiatry and Behavioral Sciences, Howard Hughes Medical Institute, Stanford University
- Sang Jeong Kim
- Department of Physiology, College of Medicine, Seoul National University
- Joo Min Park
- Center for Cognition and Sociality, Institute for Basic Science (IBS)
- Min Whan Jung
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- Se-Bum Paik
- Program of Brain and Cognitive Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute for Science and Technology (KAIST)
- Eunjoon Kim
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- DOI
- https://doi.org/10.1038/s41467-021-25356-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
How NMDAR and GABA neuronal dysfunctions result in impaired social behaviour is unclear. Here, the authors show that NMDARs and gap junctions in cortical PV interneurons modulate burst firing, affecting social behaviour.
