Pathophysiology of Non Alcoholic Fatty Liver Disease

Abstract

The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circulating lipids, mediators released by adipose, muscle and liver tissues and pancreatic and gut hormones in relation to diet, exercise and inflammation.

Keywords

• fatty liver
• insulin resistance
• free fatty acids
• cholesterol
• adiponectin
• leptin
• insulin
• glucagon
• glucagon-like peptide 1
• ghrelin
• irisin
• selenoprotein P