DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos

Yixiong Wang; Lubna Yasmin; Lei Li; Pinzhang Gao; Xia Xu; Xuejun Sun; Roseline Godbout

doi:10.1038/s41467-022-31497-9

Nature Communications (Jul 2022)

DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos

Yixiong Wang,
Lubna Yasmin,
Lei Li,
Pinzhang Gao,
Xia Xu,
Xuejun Sun,
Roseline Godbout

Affiliations

Yixiong Wang: Department of Oncology, Cross Cancer Institute, University of Alberta
Lubna Yasmin: Department of Oncology, Cross Cancer Institute, University of Alberta
Lei Li: Department of Oncology, Cross Cancer Institute, University of Alberta
Pinzhang Gao: Department of Oncology, Cross Cancer Institute, University of Alberta
Xia Xu: Department of Oncology, Cross Cancer Institute, University of Alberta
Xuejun Sun: Department of Oncology, Cross Cancer Institute, University of Alberta
Roseline Godbout: Department of Oncology, Cross Cancer Institute, University of Alberta

DOI: https://doi.org/10.1038/s41467-022-31497-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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The DEAD box protein DDX1 is known to form large aggregates in the cytoplasm of early mouse embryos. Here the authors identify DDX1-containing vesicles and show that loss of Ddx1 affects their integrity, compromising mitochondria function and causing embryonic lethality.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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