Corneal ulceration associated with Nivolumab use

Abstract

Purpose: To describe a case of corneal ulceration associated with Nivolumab use. Observations: An 80-year-old woman treated with Nivolumab for metastatic melanoma developed an intractable corneal ulcer in her left eye, refractory to all therapies – including surgery to cover the ulcer with a conjunctival flap – until topical prednisolone acetate was tried, which was curative. Conclusions and importance: Nivolumab use may be associated with a form of steroid-responsive corneal ulceration. Keywords: Cornea, Corneal ulcer, Nivolumab, Opdivo, Peripheral ulcerative keratitis