A Case of Breast Cancer with Neuroendocrine Differentiation

Abstract

A very uncommon and different subtype of breast cancer with particular morphological and molecular characteristics is Neuroendocrine Carcinoma of the Breast (NECB). A 59-year-old female patient presented to the Department of Surgery with a chief complaint of a lump in the right breast, reported to the Department of Surgery whose breast neuroendocrine cancer was diagnosed. After undergoing imaging tests and presenting with a palpable breast lump, the patient’s lesion turned out to be worrisome. Neuroendocrine cancer was identified by Fine Needle Aspiration Cytology (FNAC) and subsequent histological analysis. The diagnosis was confirmed by immunohistochemical investigation, which revealed positive staining for neuroendocrine markers. As part of a multimodal treatment regimen, the patient underwent surgery, chemotherapy, and hormonal therapy. Follow-up imaging and clinical examination demonstrated a favourable response to medication, with no indication of a return of the illness. The present case study highlights the importance of NECB as a distinct entity requiring specific care and diagnostic methods. More investigation was required to better understand the best management approaches for this uncommon kind of breast cancer. Reviewing the current state of knowledge about the incidence, demographics, diagnosis, histopathology, staining characteristics of NECB, prognostic factors, differential diagnosis, and available treatments is crucial. During the 12-month follow-up, the patient showed improvement in her clinical condition after receiving adjuvant chemotherapy and hormone treatment. The present instance highlights the need for tailored treatment strategies in circumstances like this and highlights the significance of being vigilant in detecting neuroendocrine differentiation within breast cancer.

Keywords

• fine needle aspiration cytology
• immunohistochemistry
• neuroendocrine tumour
• solid lesion