P-glycoprotein functional activity and expression in type 2 alloxan diabetes

Abstract

On 16 Chinchilla rabbits males of breed with type 2 alloxan diabetes P-glycoprotein functional activity and expression was studied. The diabetes mellitus was modelled by intravenous administration of alloxan monohydrate in the citrate buffer. P-glycoprotein functional activity was assessed by pharmacokinetics of its probe substrate - fexofenadine after its single oral administration. P-glycoprotein expression was investigated by immunohistochemistry method. The inhibition of P-glycoprotein functional activity and expression was followed by decrease of postprandial insulin level and an insulinogenic index and increase of postprandial glucose level in a blood.

Keywords

• гликопротеин-P
• ABCB1-белок
• функциональная активность
• экспрессия
• аллоксан-индуцированный сахарный диабет 2 типа