Relation of diabetic retinopathy in rats and connective tissue growth factor as well as the intervetion effect of Xueshuantong

Abstract

AIM:To explore the effects of connective tissue growth factor(CTGF)on diabetic retinopathy(DR)in rats,and the potential protective mechanism of compound xueshuantong to DR.METHODS:Sprague-Dawley(SD)rats were divided into normal group(group a,n=12)and model group(n=24). Rats in model group received intraperitoneal injection of streptozotocin(60mg/kg body weight)to get diabetic rats,which were randomly subdivided into diabetic group(group B,n=12)and xueshuantong intervention group \〖group C,1g/(kg·d),n=12\〗. At 6th and 12th wk of the experiment, 6 rats randomly selected from every group,were executed to get retinal tissue for detecting CTGF-mRNA by electron microscope. RESULTS:Compared with group A,the content of CTGF-mRNA in retina tissue increased at 6, 12wk in both group B and C(PPCONCLUSION:CTGF may be involved in the progress of DR in diabetic rats. Compound xueshuantong may exert its protective effect through decreasing the expression of CTGF in the retina of diabetic rats.

Keywords

• diabetic retinopathy
• connective tissue growth factor
• diabetic rats