Bilateral malignant ovarian tumor: a rare combination of mixed epithelial tumor - serous adenocarcinoma with Brenner’s and pure Brenner’s tumor

Abstract

Mixed epithelial ovarian tumors, by definition are composed of admixtures of two or more of the five major cell types: serous, mucinous, endometroid, clear cell and Brenner/ transitional. According to WHO, neoplasms containing minor component more than 10% named as mixed carcinomas. These tumors comprise less than 4% of all the ovarian epithelial stromal neoplasms. We present a case of a 54year old postmenopausal women presented with lower abdominal pain for 3months, mass per abdomen for 1month. Ultrasonography revealed a bilateral ovarian mass suggestive of malignant cystadenoma. With high CA 125 (498.5U/ml) favored ovarian malignancy, planned for staging laparotomy and proceed. Histopathology revealed malignant Brenner tumor in left ovary and malignant mixed epithelial tumor composed of malignant Brenner tumor with high grade serous carcinoma (50%) in right ovary. Mixed epithelial tumors are rare and pose a diagnostic dilemma; multiple histopathological sections should be evaluated to rule out the presence of dual neoplasm.

Keywords

• mixed epithelial ovarian tumor
• malignant brenner
• high grade serous cystadenoma