A general strategy for prepared multifunction double-ions agarose hydrogel dressing promotes wound healing

Junlong Tian; Jinyi Peng; Chengjun Hu; Shaorong Lei; Dingyu Wu

Materials & Design (Apr 2024)

A general strategy for prepared multifunction double-ions agarose hydrogel dressing promotes wound healing

Junlong Tian,
Jinyi Peng,
Chengjun Hu,
Shaorong Lei,
Dingyu Wu

Affiliations

Junlong Tian: Department of Electronic Science, College of Big Data and Information Engineering, Guizhou University, Guiyang 550025, China; Hunan Key Laboratory of Micro-Nano Energy Materials and Devices, School of Physics and Optoelectronic, Xiangtan University, Xiangtan, Hunan 411105, China; Corresponding authors at: Department of Electronic Science, College of Big Data and Information Engineering, Guizhou University, Guiyang 550025, China (J. Tian).
Jinyi Peng: Department of Electronic Science, College of Big Data and Information Engineering, Guizhou University, Guiyang 550025, China; Hunan Key Laboratory of Micro-Nano Energy Materials and Devices, School of Physics and Optoelectronic, Xiangtan University, Xiangtan, Hunan 411105, China
Chengjun Hu: Department of Plastic Surgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
Shaorong Lei: Department of Plastic Surgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China; Corresponding authors at: Department of Electronic Science, College of Big Data and Information Engineering, Guizhou University, Guiyang 550025, China (J. Tian).
Dingyu Wu: Department of Plastic Surgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China; Corresponding authors at: Department of Electronic Science, College of Big Data and Information Engineering, Guizhou University, Guiyang 550025, China (J. Tian).

Journal volume & issue: Vol. 240
p. 112854

Abstract

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In this study, a new multifunctional double-ions macro-porous agarose hydrogel dressing is proposed, which successfully loaded Ag+ and Li+ simultaneously through the interaction of hydrogen bonds on carboxymethyl agarose (CMA) molecular chains and the interaction of carboxymethyl with metal ions. The macro-porous double-ions hydrogel dressing shows excellent biocompatibility, water-absorbing and water retention capabilities, as well as pH and temperature response characteristics. Moreover, Ag+ ions can be released in the early stage of treatment and Li+ ions can be released steadily and controlled for a long time throughout the treatment, which contributed to effectively antibacterial, and promote tissue regeneration, accelerate wound healing. Significantly, this work provides a general strategy for prepared multifunction double-ions hydrogel dressing with interconnected pores, not limited only to Ag+ and Li+ double-ions, but also Ag+ and Cu2+ double-ions, and Li+ and Cu2+ double-ions, and so on. Thus, the multifunction double-ions hydrogel exhibits a great potential in becoming an effective, efficient and economical wound management dressing. Moreover, this work presents a promising strategy in providing the agarose hydrogel wound dressing to achieve personalized customization ideas.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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