Nature Communications (Nov 2021)

Resurgent Na+ currents promote ultrafast spiking in projection neurons that drive fine motor control

  • Benjamin M. Zemel,
  • Alexander A. Nevue,
  • Andre Dagostin,
  • Peter V. Lovell,
  • Claudio V. Mello,
  • Henrique von Gersdorff

DOI
https://doi.org/10.1038/s41467-021-26521-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 23

Abstract

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The zebra finch robust nucleus of the arcopallium (RA) directs singing by providing descending projections to brainstem motor neurons. The authors show that electrophysiological characteristics of RA neurons rely on resurgent Na+ currents that emerge early during song development only in males.