A surprising new route to 4-nitro-3-phenylisoxazole

Abstract

A one-pot synthesis of 4-nitro-3-phenylisoxazole has been carried out by treatment of cinnamyl alcohol dissolved in acetic acid with sodium nitrite; in addition, 4-phenyl-3-furoxanmethanol was obtained in 40% yield.

Keywords

• cinnamyl alcohol
• furoxan derivatives
• isoxazole derivatives
• X-ray diffraction