SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival

Hexiu Su; Juncheng Hu; Liang Huang; Yang Yang; Morgan Thenoz; Anna Kuchmiy; Yufeng Hu; Peng Li; Hui Feng; Yu Zhou; Tom Taghon; Pieter Van Vlierberghe; Guoliang Qing; Zhichao Chen; Hudan Liu

doi:10.1038/s41467-018-06523-4

Nature Communications (Oct 2018)

SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival

Hexiu Su,
Juncheng Hu,
Liang Huang,
Yang Yang,
Morgan Thenoz,
Anna Kuchmiy,
Yufeng Hu,
Peng Li,
Hui Feng,
Yu Zhou,
Tom Taghon,
Pieter Van Vlierberghe,
Guoliang Qing,
Zhichao Chen,
Hudan Liu

Affiliations

Hexiu Su: Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Juncheng Hu: Medical Research Institute, Wuhan University
Liang Huang: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Yang Yang: College of Life Sciences, Wuhan University
Morgan Thenoz: Department of Biomolecular Medicine, Ghent University
Anna Kuchmiy: Department of Clinical Chemistry, Microbiology and Immunology, Ghent University
Yufeng Hu: Zhongnan Hospital of Wuhan University
Peng Li: South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Hui Feng: Department of Pharmacology and Department of Medicine, Cancer Research Center, Section of Hematology and Medical Oncology, Boston University School of Medicine
Yu Zhou: College of Life Sciences, Wuhan University
Tom Taghon: Department of Clinical Chemistry, Microbiology and Immunology, Ghent University
Pieter Van Vlierberghe: Department of Biomolecular Medicine, Ghent University
Guoliang Qing: Medical Research Institute, Wuhan University
Zhichao Chen: Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Hudan Liu: Medical Research Institute, Wuhan University

DOI: https://doi.org/10.1038/s41467-018-06523-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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T-acute lymphoblastic leukemia is an aggressive cancer. Here the authors provide insights into the functional role of SHQ1, an H/ACA snoRNP assembly factor involved in snRNA pseudouridylation, in T-lymphoblastic leukemia cell survival through regulating the maturation of MYC mRNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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