mSystems (Oct 2021)

Viral Inactivation Impacts Microbiome Estimates in a Tissue-Specific Manner

  • Alba Boix-Amorós,
  • Enrica Piras,
  • Kevin Bu,
  • David Wallach,
  • Matthew Stapylton,
  • Ana Fernández-Sesma,
  • Dolores Malaspina,
  • Jose C. Clemente

DOI
https://doi.org/10.1128/mSystems.00674-21
Journal volume & issue
Vol. 6, no. 5

Abstract

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Understanding how viral infections impact and are modulated by the microbiome is an important problem in basic research but is also of high clinical relevance under the current pandemic. To facilitate the study of interactions between microbial communities and pathogenic viruses under safe conditions, the infectious agent is generally inactivated prior to processing samples.