mSystems
(Oct 2021)
Viral Inactivation Impacts Microbiome Estimates in a Tissue-Specific Manner
Alba Boix-Amorós,
Enrica Piras,
Kevin Bu,
David Wallach,
Matthew Stapylton,
Ana Fernández-Sesma,
Dolores Malaspina,
Jose C. Clemente
Affiliations
Alba Boix-Amorós
ORCiD
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Enrica Piras
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Kevin Bu
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
David Wallach
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Matthew Stapylton
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Ana Fernández-Sesma
Department of Microbiology, Icahn School of Medicine at Mount Sinai. New York, New York, USA
Dolores Malaspina
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Jose C. Clemente
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
DOI
https://doi.org/10.1128/mSystems.00674-21
Journal volume & issue
Vol. 6,
no. 5
Abstract
Read online
Understanding how viral infections impact and are modulated by the microbiome is an important problem in basic research but is also of high clinical relevance under the current pandemic. To facilitate the study of interactions between microbial communities and pathogenic viruses under safe conditions, the infectious agent is generally inactivated prior to processing samples.
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