Comparative Proteomic Analysis of Protein Patterns of <i>Stenotrophomonas maltophilia</i> in Biofilm and Planktonic Lifestyles

Abstract

Stenotrophomonas maltophilia is a clinically relevant bacterial pathogen, particularly in cystic fibrosis (CF) patients. Despite the well-known ability to form biofilms inherently resistant to antibiotics and host immunity, many aspects involved in S. maltophilia biofilm formation are yet to be elucidated. In the present study, a proteomic approach was used to elucidate the differential protein expression patterns observed during the planktonic-to-biofilm transition of S. maltophilia Sm126, a strong biofilm producer causing chronic infection in a CF patient, to identify determinants potentially associated with S. maltophilia biofilm formation. In all, 57 proteins were differentially (3-fold; p S. maltophilia.

Keywords

• <i>Stenotrophomonas maltophilia</i>
• biofilm formation
• proteomic analysis
• cystic fibrosis