Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinedionesas Anti-Angiogenesis Agents

Abstract

A series of novel 3-N-sugar-substituted quinazolinediones were synthesizedthrough the cyclization of the intermediate 2-aminobenzamides using triphosgene as the condensing reagent. Their anti-angiogenesis activities were investigated. The compound 3-(2'-aminoglucosyl)-2,4-(1H,3H)-quinazolinedione, (5d) showed good anti-angiogenesis activity.

Keywords

• quinazolinediones
• anti-angiogenesis
• triphosgene