Could neutrophil-to-lymphocyte ratio be an important parameter in children and adolescents with obsessive compulsive disorder? (eng)

Abstract

Objective: The number of studies that suggest the possible role of immune abnormalities in the pathogenesis of obsessive-compulsive disorder(OCD) are increasing. Our aim here is to determine the relationship between neutrophil lymphocyte ratio(NLR) and children and adolescents with OCD.NLR and platelet lymphocyte ratio(PLR) are new, inexpensive, easily reproducible indicators used for the determination of low grade inflammation. Method: In this study, retrospective records of 32 children and adolescents with OCD were screened, and the NLR, PLR,monocyte lymphocyte ratio (MLR) data obtained from the pre-treatment complete blood count were compared with the same data of the healthy control group with similar characteristics. Results: The NLR was found lower in children and adolescents with OCD compared to the control group; yet PLR and MLR were not significantly different. Conclusion: Inflammation might play a role in the etiopahogenesis of OCD. The NLR may be potential inlammation markers for OCD in children.

Keywords

• obsessive-compulsive disorder
• child psychiatry
• inflammation
• neutrophil to lymphocyte ratio