Nature Communications (Sep 2022)

Deciphering multi-way interactions in the human genome

  • Gabrielle A. Dotson,
  • Can Chen,
  • Stephen Lindsly,
  • Anthony Cicalo,
  • Sam Dilworth,
  • Charles Ryan,
  • Sivakumar Jeyarajan,
  • Walter Meixner,
  • Cooper Stansbury,
  • Joshua Pickard,
  • Nicholas Beckloff,
  • Amit Surana,
  • Max Wicha,
  • Lindsey A. Muir,
  • Indika Rajapakse

DOI
https://doi.org/10.1038/s41467-022-32980-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

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Mapping higher order chromatin architecture is important. Here the authors use long sequencing reads to map genome-wide multi-way contacts and investigate higher order chromatin organisation; they use hypergraph theory for data representation and analysis, and apply this to different cell types.