Secondary hemophagocytic syndrome in an acquired immunodeficiency syndrome and Alpha-thalassemia patient infected with Talaromyces marneffei: A case report and literature review
Qingqing Wu,
Yixiu Yu,
Shenhong Feng,
Bingqian Fang,
Renzhi Zheng,
Weidong Sun,
Jianzhi Zhao
Affiliations
Qingqing Wu
Department of Hematology, Shaoxing Central Hospital, The Central Hospital of Shaoxing University, Shaoxing 312030, China
Yixiu Yu
Department of Hematology, Shaoxing Central Hospital, The Central Hospital of Shaoxing University, Shaoxing 312030, China
Shenhong Feng
Department of Hematology, Shaoxing Central Hospital, The Central Hospital of Shaoxing University, Shaoxing 312030, China
Bingqian Fang
Department of Hematology, Shaoxing Central Hospital, The Central Hospital of Shaoxing University, Shaoxing 312030, China
Renzhi Zheng
Department of Hematology, Shaoxing Central Hospital, The Central Hospital of Shaoxing University, Shaoxing 312030, China
Weidong Sun
Department of Hematology, Shaoxing Central Hospital, The Central Hospital of Shaoxing University, Shaoxing 312030, China
Jianzhi Zhao
Corresponding author.; Department of Hematology, Shaoxing Central Hospital, The Central Hospital of Shaoxing University, Shaoxing 312030, China
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease characterized by a hyperinflammatory syndrome and impairment of multiple organ systems. Talaromycosis marneffei (TSM) is an opportunistic infection mostly found in immunosuppressed populations, such as those with acquired immunodeficiency syndrome (AIDS), and is prevalent in southern China. However, HLH secondary to TSM is extremely rare and has only been reported in isolated cases. A 30-year-old patient with recurrent high fever and progressive cytopenia was diagnosed with HLH secondary to disseminated TSM with AIDS and Alpha-thalassemia. The patient remained in sustained remission without recurrence after effective treatment with antifungals and glucocorticoids.
