Nature Communications (Nov 2017)
Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease
Abstract
Cerebrovascular changes and astrogliosis occur in Alzheimer’s disease (AD). Using an in vivo phage display technique, the authors identified a peptide that upon systematic administration, can home to brain endothelial cells and astrocytes in mouse models of AD at the early stages of the disease.