Nature Communications (Nov 2017)

Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease

  • Aman P. Mann,
  • Pablo Scodeller,
  • Sazid Hussain,
  • Gary B. Braun,
  • Tarmo Mölder,
  • Kadri Toome,
  • Rajesh Ambasudhan,
  • Tambet Teesalu,
  • Stuart A. Lipton,
  • Erkki Ruoslahti

DOI
https://doi.org/10.1038/s41467-017-01096-0
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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Cerebrovascular changes and astrogliosis occur in Alzheimer’s disease (AD). Using an in vivo phage display technique, the authors identified a peptide that upon systematic administration, can home to brain endothelial cells and astrocytes in mouse models of AD at the early stages of the disease.