Nature Communications (Oct 2017)

Molecular rheotaxis directs DNA migration and concentration against a pressure-driven flow

  • Sarah M. Friedrich,
  • Jeffrey M. Burke,
  • Kelvin J. Liu,
  • Cornelius F. Ivory,
  • Tza-Huei Wang

DOI
https://doi.org/10.1038/s41467-017-01214-y
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Implementing a nucleic acid preconcentration method can improve the sensitivity of microfluidic analysis systems. Here Friedrich et al. concentrate DNA by many orders of magnitude using pressure-driven flow, which could lead to a simple and practical microanalysis platform.