Nature Communications (Dec 2019)

Deciphering protein evolution and fitness landscapes with latent space models

  • Xinqiang Ding,
  • Zhengting Zou,
  • Charles L. Brooks III

DOI
https://doi.org/10.1038/s41467-019-13633-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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Multiple sequence alignments of proteins carry information about evolution, the protein’s fitness landscape and its stability in the face of mutations. Here, the authors demonstrate the utility of latent space models learned using variational autoencoders to infer these properties from sequences.